Antagonist anti-CD40 antibody CHIR-12.12 causes tumor regression and prolongs survival in multiple myeloma xenograft models.

被引:0
|
作者
Long, L [1 ]
Tong, X [1 ]
Patawaran, M [1 ]
Aukerman, L [1 ]
Jallal, B [1 ]
Luqman, M [1 ]
机构
[1] Chiron Corp, Emeryville, CA 94608 USA
关键词
D O I
10.1182/blood.V104.11.4888.4888
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
4888
引用
收藏
页码:304B / 304B
页数:1
相关论文
共 50 条
  • [31] The humanized anti-CD40 monoclonal antibody, SGN-40, potentiates chemotherapy regimens in NHL xenograft models via pro-apoptotic signaling
    Lewis, Timothy S.
    McCormick, Renee S.
    Kissler, Kim
    Stone, Ivan J.
    Jonas, Mechthild
    Sutherland, May S. K.
    Gerber, Hans-Peter
    Drachman, Jonathan. G.
    Grewal, Iqbal S.
    Law, Che-Leung
    BLOOD, 2007, 110 (11) : 692A - 693A
  • [32] hCD122, an antagonist human Anti-CD40 monoclonal antibody, enhances efficacy of CHOP in tumor xenograft model of human diffuse large B-Cell lymphoma.
    Luqman, Mohammad
    Hsu, Ssucheng J.
    Ericson, Matthew
    Klabunde, Sha
    Kantak, Seema
    BLOOD, 2007, 110 (11) : 162A - 162A
  • [33] HCD122, an antagonist human anti-CD40 monoclonal antibody, inhibits tumor growth in xenograft models of human diffuse large B-Cell lymphoma, a subset of non-hodgkins lymphoma.
    Hsu, Ssucheng J.
    Esposito, Lin A.
    Aukerman, Sharon L.
    Kantak, Seema
    Mirza, Amer M.
    BLOOD, 2006, 108 (11) : 713A - 713A
  • [34] Recombinant humanized anti-CD40 monoclonal antibody triggers autologous antibody-dependent cell-mediated cytotoxicity against multiple myeloma cells
    Hayashi, T
    Treon, SP
    Hideshima, T
    Tai, YT
    Akiyama, M
    Richardson, P
    Chauhan, D
    Grewal, IS
    Anderson, KC
    BRITISH JOURNAL OF HAEMATOLOGY, 2003, 121 (04) : 592 - 596
  • [35] A Novel, Blocking, Fc-Silent Anti-CD40 Monoclonal Antibody Prolongs Nonhuman Primate Renal Allograft Survival in the Absence of B Cell Depletion
    Cordoba, F.
    Wieczorek, G.
    Audet, M.
    Roth, L.
    Schneider, M. A.
    Kunkler, A.
    Stuber, N.
    Erard, M.
    Ceci, M.
    Baumgartner, R.
    Apolloni, R.
    Cattini, A.
    Robert, G.
    Ristig, D.
    Munz, J.
    Haeberli, L.
    Grau, R.
    Sickert, D.
    Heusser, C.
    Espie, P.
    Bruns, C.
    Patel, D.
    Rush, J. S.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15 (11) : 2825 - 2836
  • [36] A chimeric humanized anti-CD40 antibody renders human multiple myeloma (MM) cells refractory to the mitogenic and protective effects of IL-6
    Tai, YT
    Mitsiades, CS
    Catley, LP
    Burger, R
    Podar, K
    Shringarpure, R
    Hideshima, T
    Chauhan, D
    Hamasaki, M
    Ishitsuka, K
    Richardson, P
    Munshi, N
    Treon, S
    Anderson, K
    BLOOD, 2003, 102 (11) : 935A - 935A
  • [37] Cross-linking of CD40 using anti-CD40 antibody, 5C11, has different effects on XG2 multiple myeloma cells
    Qi, CH
    Zheng, L
    Zhou, X
    Tao, Y
    Ge, Y
    Zhuang, YM
    Xu, Y
    Yu, GH
    Zhang, XG
    IMMUNOLOGY LETTERS, 2004, 93 (2-3) : 151 - 158
  • [38] A Novel, Blocking Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B-Cell Depletion Or Thromboembolic Events
    Rush, J.
    Wieczorek, G.
    Audet, M.
    Schneider, M.
    Espie, P.
    Roth, L.
    Heusser, C.
    Bruns, C.
    Patel, D.
    Cordoba, F.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15
  • [39] A NOVEL, BLOCKING ANTI-CD40 MONOCLONAL ANTIBODY PROLONGS NON-HUMAN PRIMATE RENAL ALLOGRAFT SURVIVAL IN THE ABSENCE OF B-CELL DEPLETION OR THROMBOEMBOLIC EVENTS
    Cordoba, Francisco
    Wieczorek, Grazyna
    Audet, Maxime
    Schneider, Martin A.
    Espie, Pascal
    Roth, Lukas
    Heusser, Christoph
    Bruns, Christian
    Patel, Dhavalkumar
    Haraldsson, Boerje
    Rush, James S.
    TRANSPLANT INTERNATIONAL, 2015, 28 : 123 - 123
  • [40] A novel, blocking anti-CD40 monoclonal antibody prolongs non-human primate renal allograft survival in the absence of B-cell depletion or thromboembolic events
    Cordoba, F.
    Wieczorek, G.
    Audet, M.
    Schneider, M.
    Espie, P.
    Roth, L.
    Heusser, C.
    Bruns, C.
    Patel, D.
    Rush, J.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 764 - 764