A Knockout Combo: Eradicating AML Stem Cells with TKI plus SIRT1 Inhibition

被引：2
|
作者：
Zeisig, Bernd B. [1 ]
So, Chi Wai Eric [1 ]
机构：
[1] Kings Coll London, Div Canc Studies, Dept Haematol Med, Leukaemia & Stem Cell Biol Grp, London WC2R 2LS, England
来源：
CELL STEM CELL | 2014年 / 15卷 / 04期
基金：
英国医学研究理事会;
关键词：
ACUTE MYELOID-LEUKEMIA; ACTIVATION; CANCER; EVOLUTION; P53;
D O I：
10.1016/j.stem.2014.09.006
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
SIRT1 inhibition facilitates elimination of CML stem cells by Imatinib, in part via p53 activation. In this issue of Cell Stem Cell, Li et al. (2014) demonstrate a similar role for SIRT1 inhibition in eradicating FLT3-ITD AML stem cells, potentially through a positive feedback loop with c-MYC, highlighting SIRT1 as a potential target in combination cancer therapy.
引用
收藏
页码：395 / 397
页数：3
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