Revert the SIRT: Normalizing SIRT1 Activity in Myelodysplastic Stem Cells

被引：4
|
作者：
Simeoni, Fabrizio [1 ]
Somervaille, Tim C. P. [1 ]
机构：
[1] Univ Manchester, Canc Res UK Manchester Inst, Leukaemia Biol Lab, Manchester M20 4JG, Lancs, England
来源：
CELL STEM CELL | 2018年 / 23卷 / 03期
关键词：
ACTIVATION;
D O I：
10.1016/j.stem.2018.08.003
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Myelodysplastic syndromes are hematologic malignancies with few treatment options and a propensity to transform to acute myeloid leukemia. In this issue of Cell Stem Cell, Sun et al. (2018) report that low SIRT1 levels in myelodysplastic stem cells contribute to aberrant self-renewal through enabling hyperacetylation and reduced activity of TET2.
引用
收藏
页码：315 / 317
页数：4
相关论文
共 50 条
  • [1] Effects of toxoflavin on the activity of SIRT1 and SIRT2
    Jeong, Y.
    Kim, E.
    Chin, Y-W.
    Han, S-Y.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24
  • [2] SIRT1 DEACETYLASE IS ESSENTIAL FOR HEMATOPOIETIC STEM CELL ACTIVITY
    Rimmele, Pauline
    Bigarella, Carolina
    d'Escamard, Valentina
    Izac, Brigitte
    Sinclair, David
    Ghaffari, Saghi
    EXPERIMENTAL HEMATOLOGY, 2013, 41 (08) : S35 - S35
  • [3] Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
    Knight, John R. P.
    Allison, Simon J.
    Milner, Jo
    OPEN BIOLOGY, 2013, 3 (11)
  • [4] Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
    Chen, Huiqiang
    Liu, Xianbao
    Chen, Han
    Cao, Jiang
    Zhang, Ling
    Hu, Xinyang
    Wang, Jian'an
    AGEING RESEARCH REVIEWS, 2014, 13 : 55 - 64
  • [5] SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases
    Manjula, Ramu
    Anuja, Kumari
    Alcain, Francisco J.
    FRONTIERS IN PHARMACOLOGY, 2021, 11
  • [6] Metabolic benefits from Sirt1 and Sirt1 activators
    Chaudhary, Nilika
    Pfluger, Paul T.
    CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2009, 12 (04): : 431 - 437
  • [7] SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
    Leko, Vid
    Varnum-Finney, Barbara
    Li, Hongzhe
    Gu, Yansong
    Flowers, David
    Nourigat, Cynthia
    Bernstein, Irwin D.
    Bedalov, Antonio
    BLOOD, 2012, 119 (08) : 1856 - 1860
  • [8] SIRT1 Inhibition Sensitizes CML Stem Cells to Imatinib Treatment
    不详
    CANCER DISCOVERY, 2012, 2 (04)
  • [9] SIRT1 regulates metabolism and leukemogenic potential in CML stem cells
    Abraham, Ajay
    Qiu, Shaowei
    Chacko, Balu K.
    Li, Hui
    Paterson, Andrew
    He, Jianbo
    Agarwal, Puneet
    Shah, Mansi
    Welner, Robert
    Darley-Usmar, Victor M.
    Bhatia, Ravi
    JOURNAL OF CLINICAL INVESTIGATION, 2019, 129 (07): : 2685 - 2701
  • [10] The variable role of SIRT1 in the maintenance and differentiation of mesenchymal stem cells
    Zainabadi, Kayvan
    REGENERATIVE MEDICINE, 2018, 13 (03) : 343 - 356
12345