Protective constituents against sepsis in mice from the root cortex of Paeonia suffruticosa

被引：36

作者：

Li, G

Seo, CS

Lee, KS

Kim, HJ

Chang, HW

Jung, JS

Song, DK

Son, JK ^{[1
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

[2] Yanbian Univ, Coll Pharm, Yanji 133000, Peoples R China

[3] Hallym Univ, Coll Med, Dept Pharmacol, Inst Nat Med, Chunchon 200702, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 11期

关键词：

Paeonia suffruticosa; sepsis; LPS; D-GaIN; ALT;

D O I：

10.1007/BF02975116

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.

引用

页码：1123 / 1126

页数：4

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