Synthesis and Biological Evaluation of 1-Cyclohexyl Substituted 3-Aminopyrrolidine Derivatives as CC Chemokine Receptor 2 (CCR2) Antagonists

被引：1
|
作者：
Lim, Jee Woong [1 ,5 ]
Na, Yongho [1 ]
Oak, Min-Ho [2 ]
Kim, Jong-Hoon [1 ,3 ]
Oh, Youna [1 ]
Lee, Seung-Woo [1 ]
Cho, Heeyeong [4 ]
Park, Woo-Kyu [4 ]
Choi, Gildon [4 ]
Kim, Kyoung Rak [1 ]
Kang, Jongmin [5 ]
机构：
[1] Gyeonggi Bioctr, Suwon 443766, South Korea
[2] Hanwha Pharma, Ctr Res & Dev, Chunchon 200921, South Korea
[3] Yonsei Univ, Dept Biotechnol, Seoul 120749, South Korea
[4] Korea Res Inst Chem Technol, Taejon 305600, South Korea
[5] Sejong Univ, Dept Chem, Seoul 143747, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2010年 / 31卷 / 07期
关键词：
Chemokine receptor; Antagonist; Inflammation; 3-Aminopyrrolidine;
D O I：
10.5012/bkcs.2010.31.7.1827
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：1827 / 1828
页数：2
相关论文
共 50 条
  • [41] Chemokine receptor CCR2 undergoes transportin1-dependent nuclear translocation
    Favre, Nicolas
    Camps, Montserrat
    Arod, Christian
    Chabert, Christian
    Rommel, Christian
    Pasquali, Christian
    PROTEOMICS, 2008, 8 (21) : 4560 - 4576
  • [42] Genetic Ablation of CC Family Chemokine Receptor 2 (CCR2) Mitigates Muscle Dysfunction in the Dystrophic (Mdx) Mouse Diaphragm
    Liang, F.
    Danialou, G.
    Maniakas, A.
    Yim, S.
    Bourdon, J.
    Petrof, B. J.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179
  • [43] Retinal Phenotype following Combined Deletion of the Chemokine Receptor CCR2 and the Chemokine CX3CL1 in Mice
    Hagbi-Levi, Shira
    Grunin, Michelle
    Elbaz-Hayoun, Sarah
    Tal, David
    Obolensky, Alexey
    Hanhart, Joel
    Banin, Eyal
    Burstyn-Cohen, Tal
    Chowers, Itay
    OPHTHALMIC RESEARCH, 2016, 55 (03) : 126 - 134
  • [44] Inhibitors of monocyte chemoattractant protein-1/CC ligand 2 and its receptor CCR2
    Howard, OMZ
    Yoshimura, T
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2001, 11 (07) : 1147 - 1151
  • [45] CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD
    Falk, Mads Kruger
    Singh, Amardeep
    Faber, Carsten
    Nissen, Mogens Holst
    Hviid, Thomas
    Sorensen, Torben Lykke
    PLOS ONE, 2014, 9 (12):
  • [46] Transplantation of monocyte CC-chemokine receptor 2 (CCR2) deficient bone marrow into ApoE3-Leiden mice inhibits atherogenesis
    Guo, J
    Eck, MV
    Twisk, J
    Maeda, N
    Groot, P
    Berkel, TV
    CIRCULATION, 2002, 105 (14) : E105 - E105
  • [47] Decreased lesion formation in CC chemokine receptor 2 (CCR2) knockout mice reveals an important role for MCP-1 in the development of atherosclerosis
    Boring, LF
    Gosling, JA
    Cleary, MD
    Charo, F
    CIRCULATION, 1998, 98 (17) : 309 - 309
  • [48] Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2)
    Kim, Y
    Sung, SSJ
    Kuziel, WA
    Feldman, S
    Fu, SM
    Rose, CE
    JOURNAL OF IMMUNOLOGY, 2001, 166 (08): : 5183 - 5192
  • [49] Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells
    Corcione, A
    Tortolina, G
    Bonecchi, R
    Battilana, N
    Taborelli, G
    Malavasi, F
    Sozzani, S
    Ottonello, L
    Dallegri, F
    Pistoia, V
    INTERNATIONAL IMMUNOLOGY, 2002, 14 (08) : 883 - 892
  • [50] A genetic variation in the promoter of the gene encoding chemokine CC motif receptor 2 (CCR2) associates with flow-mediated vasodilation
    Machicao, Fausto
    Rittig, Kilian
    Balletshofer, Bernd
    Staiger, Harald
    Stefan, Norbert
    Fritsche, Andreas
    Haering, Hans-Ulrich
    DIABETES, 2006, 55 : A546 - A547
12345