In situ formation of protein-polymer conjugates through reversible addition fragmentation chain transfer polymerization

被引：198
|
作者：
Liu, Jingquan [1 ]
Bulmus, Volga [1 ]
Herlambang, David L. [1 ]
Barner-Kowollik, Christopher [1 ]
Stenzel, Martina H. [1 ]
Davis, Thomas P. [1 ]
机构：
[1] Univ New S Wales, CAMD, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 17期
关键词：
polymer conjugates; polymerization; protein conjugates; radiation;
D O I：
10.1002/anie.200604922
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A good place for rafting: Bovine serum albumin (BSA) was site-specifically modified with a reversible addition fragmentation chain transfer (RAFT) agent and used in γ-radiation-initiated polymerization of oligo(ethylene glycol) acrylate. Well-defined polymer chains were formed at the RAFT agent conjugation site of BSA leading to the generation of BSA-polymer conjugates in situ. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3099 / 3103
页数：5
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