Synthesis of P-chiral, non-racemic phosphinylacetates via enzymatic resolution of racemates

被引：0
|
作者：
Kielbasinski, P
Zurawinski, R
Pietrusiewicz, KM
Zablocka, M
Mikolajczyk, M
机构：
[1] Polish Acad Sci, Ctr Mol & Macromol Studies, PL-90363 Lodz, Poland
[2] Marie Curie Sklodowska Univ, Dept Chem, PL-20031 Lublin, Poland
来源：
POLISH JOURNAL OF CHEMISTRY | 1998年 / 72卷 / 03期
关键词：
chiral phosphine oxides; enzymatic hydrolysis; kinetic resolution;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of racemic methyl phosphinylacetates was hydrolyzed in the presence of porcine liver esterase (PLE) under the kinetic resolution conditions to give the corresponding P-chiral phosphinylacetic acids and recovered esters in high enantiomeric purity (72-100% ee). The Jones' active site model was applied to explain the enantioselectivity of this reaction.
引用
收藏
页码：564 / 572
页数：9
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