Studies on enzymatic synthesis of chiral non-racemic 3-arylglutaric acid monoesters

被引：20
|
作者：
Fryszkowska, Anna
Komar, Marta
Koszelewski, Dominik
Ostaszewski, Ryszard
机构：
[1] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland
[2] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland
来源：
TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 06期
关键词：
D O I：
10.1016/j.tetasy.2006.03.002
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The enantioselective enzymatic desymmetrization (EED) of various 3-arylglutaric anhydrides I with alcohols in organic media has been studied. The effect of the solvent on the stereochemical outcome of the reaction was investigated in detail. The amount of biocatalyst was optimized, and the possibility of its re-use was tested. The first example of the EED of 3-substituted glutaric anhydrides with esters as nucleophiles is reported. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：961 / 966
页数：6
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