Femtosecond laser bone ablation with a high repetition rate fiber laser source

被引：35

作者：

Mortensen, Luke J. ^{[1
,2
,3
]}

Alt, Clemens ^{[2
,3
]}

Turcotte, Raphael ^{[2
,3
,4
]}

Masek, Marissa ^{[2
,3
]}

Liu, Tzu-Ming ^{[2
,3
,5
]}

Cote, Daniel C. ^{[6
]}

Xu, Chris ^{[7
]}

Intini, Giuseppe ^{[1
,8
]}

Lin, Charles P. ^{[2
,3
,8
]}

机构：

[1] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Adv Microscopy Program,Ctr Syst Biol, Boston, MA USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA USA

[4] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[5] Natl Taiwan Univ, Inst Biomed Engn, Taipei 10764, Taiwan

[6] Univ Laval, Ctr Rech Univ Laval Robert Giffard, Quebec City, PQ G1J 2G3, Canada

[7] Cornell Univ, Sch Appl & Engn Phys, Ithaca, NY USA

[8] Harvard Stem Cell Inst, Cambridge, MA USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

STEM-CELLS; MICROSCOPY; PULSES; OSTEOTOMY; DAMAGE; TISSUES; REGENERATION; FLUORESCENCE; DIELECTRICS; BREAKDOWN;

D O I：

10.1364/BOE.6.000032

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Femtosecond laser pulses can be used to perform very precise cutting of material, including biological samples from subcellular organelles to large areas of bone, through plasma-mediated ablation. The use of a kilohertz regenerative amplifier is usually needed to obtain the pulse energy required for ablation. This work investigates a 5 megahertz compact fiber laser for near-video rate imaging and ablation in bone. After optimization of ablation efficiency and reduction in autofluorescence, the system is demonstrated for the in vivo study of bone regeneration. Image-guided creation of a bone defect and longitudinal evaluation of cellular injury response in the defect provides insight into the bone regeneration process. (C) 2014 Optical Society of America

引用

页码：32 / 42

页数：11

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