Femtosecond laser bone ablation with a high repetition rate fiber laser source

被引：35
|
作者：
Mortensen, Luke J. [1 ,2 ,3 ]
Alt, Clemens [2 ,3 ]
Turcotte, Raphael [2 ,3 ,4 ]
Masek, Marissa [2 ,3 ]
Liu, Tzu-Ming [2 ,3 ,5 ]
Cote, Daniel C. [6 ]
Xu, Chris [7 ]
Intini, Giuseppe [1 ,8 ]
Lin, Charles P. [2 ,3 ,8 ]
机构：
[1] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Adv Microscopy Program,Ctr Syst Biol, Boston, MA USA
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA USA
[4] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[5] Natl Taiwan Univ, Inst Biomed Engn, Taipei 10764, Taiwan
[6] Univ Laval, Ctr Rech Univ Laval Robert Giffard, Quebec City, PQ G1J 2G3, Canada
[7] Cornell Univ, Sch Appl & Engn Phys, Ithaca, NY USA
[8] Harvard Stem Cell Inst, Cambridge, MA USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 01期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
STEM-CELLS; MICROSCOPY; PULSES; OSTEOTOMY; DAMAGE; TISSUES; REGENERATION; FLUORESCENCE; DIELECTRICS; BREAKDOWN;
D O I：
10.1364/BOE.6.000032
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Femtosecond laser pulses can be used to perform very precise cutting of material, including biological samples from subcellular organelles to large areas of bone, through plasma-mediated ablation. The use of a kilohertz regenerative amplifier is usually needed to obtain the pulse energy required for ablation. This work investigates a 5 megahertz compact fiber laser for near-video rate imaging and ablation in bone. After optimization of ablation efficiency and reduction in autofluorescence, the system is demonstrated for the in vivo study of bone regeneration. Image-guided creation of a bone defect and longitudinal evaluation of cellular injury response in the defect provides insight into the bone regeneration process. (C) 2014 Optical Society of America
引用
收藏
页码：32 / 42
页数：11
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