Enhancement of all-trans retinoic acid induced HL-60 cell differentiation by thalidomide and its metabolites

被引：14
|
作者：
Noguchi, T
Shinji, C
Kobayashi, H
Makishima, M
Miyachi, H
Hashimoto, Y
机构：
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
[2] Nihon Univ, Sch Med, Dept Biochem, Itabashi Ku, Tokyo 1738610, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2005年 / 28卷 / 03期
关键词：
thalidomide; hydroxythalidomide; retinoic acid; differentiation; tubulin;
D O I：
10.1248/bpb.28.563
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Thalidomide (Thai: 1) and its two metabolites, 5-hydroxythalidomide (5-HT: 2) and N-hydroxythalidomide (N-HT: 3), showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation. 5-HT and N-RT showed tubulin polymerization-inhibiting activity, but thalidomide did not.
引用
收藏
页码：563 / 564
页数：2
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