Transgenic mouse expressing a full-length hepatitis C virus cDNA

被引：24
|
作者：
Matsuda, J
Suzuki, M
Nozaki, C
Shinya, N
Tashiro, K
Mizuno, K
Uchinuno, Y
Yamamura, K
机构：
[1] Kikuchi Res Ctr, Chemo Sero Therapeut Res Inst, Good Lab Practice GLP Ctr, Dept Pathol, Kumamoto 86912, Japan
[2] Kumamoto Univ, Inst Mol Embryol & Genet, Dept Dev Genet, Kumamoto 862, Japan
来源：
JAPANESE JOURNAL OF CANCER RESEARCH | 1998年 / 89卷 / 02期
关键词：
hepatitis C virus; transgenic mouse; human serum amyloid P component (hSAP) promoter;
D O I：
10.1111/j.1349-7006.1998.tb00543.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatitis C virus (HCV), a major causative agent of post transfusion non-A, non-B hepatitis (NANBH), can only infect humans and chimpanzees, We produced nine transgenic mouse lines carrying a full-length HCV cDNA with the human serum amyloid P component (hSAP) promoter that can direct liver-specific expression, In one of these lines HCV mRNA and HCV core protein were detected in the liver of the transgenic mouse, although the levels of expression were very low. In addition, HCV-related antibody was detected in the serum.
引用
收藏
页码：150 / 158
页数：9
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