Association of c.461G>A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese

被引：1
|
作者：
Zhao, Z. M. [1 ]
Li, C. G. [1 ]
Hu, M. G. [1 ]
Zhao, G. D. [1 ]
Liu, R. [1 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Surg Oncol, Beijing, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 03期
关键词：
Pancreatic cancer; OGG1; gene; Risk factors; Single nucleotide polymorphisms; Cancer susceptibility; SINGLE-NUCLEOTIDE POLYMORPHISMS; BODY-MASS INDEX; REPAIR GENES; RISK-FACTORS; METAANALYSIS; POPULATION; SURVIVAL; SMOKING;
D O I：
10.4238/2014.September.5.10
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). A total of 764 Chinese Han subjects were recruited in this study. The polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods were used to detect the genotype of c. 461G>A genetic variant of OGG1. The genotype and allele frequencies were statistically different in PC patients compared with cancer-free controls. The AA genotype was statistically associated with increased PC susceptibility compared to GG wild genotype (AA vs GG, OR = 2.62, 95% CI = 1.48-4.63,.2 = 11.46, P = 0.001). Allele A could contribute to the increased risk of PC (A vs G, OR = 1.35, 95% CI = 1.08-1.69,.2 = 6.86, P = 0.009). Our data indicated that the c. 461G>A genetic variant of the OGG1 gene was associated with susceptibility to PC in a Chinese Han population.
引用
收藏
页码：7256 / 7261
页数：6
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