Detection of micro- to nano-sized particles in soft tissue

The demand is growing to study particulate debris in the human organism. This task is time-consuming. Therefore it is important to find an efficient way of particle identification and analysis. Carriers of hip replacement implants are exposed to particulate wear debris close to and even far away from the implantation sites. This could ease the study of particle transport in the human organism because detectable amounts of particulate matter are likely to arrive in distant organs with regard to the implant. A feasible approach for particle analysis down to the level of electron microscopy is presented here.