Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus

被引：42
|
作者：
Schrauwen, Eefje J. A. [1 ]
Richard, Mathilde [1 ]
Burke, David F. [2 ]
Rimmelzwaan, Guus F. [1 ]
Herfst, Sander [1 ]
Fouchier, Ron A. M. [1 ]
机构：
[1] Erasmus MC, Postgrad Sch Mol Med, Dept Virosci, Rotterdam, Netherlands
[2] Univ Cambridge, Dept Zool, Cambridge, England
来源：
JOURNAL OF VIROLOGY | 2016年 / 90卷 / 07期
关键词：
UPPER RESPIRATORY-TRACT; AIRBORNE TRANSMISSION; A VIRUS; A/H5N1; VIRUS; H5; HA; FERRETS; PH; DROPLET; PATHOGENESIS; REPLICATION;
D O I：
10.1128/JVI.03052-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Receptor-binding preference and stability of hemagglutinin have been implicated as crucial determinants of airborne transmission of influenza viruses. Here, amino acid substitutions previously identified to affect these traits were tested in the context of an A/H7N9 virus. Some combinations of substitutions, most notably G219S and K58I, resulted in relatively high affinity for alpha 2,6-linked sialic acid receptor and acid and temperature stability. Thus, the hemagglutinin of the A/H7N9 virus may adopt traits associated with airborne transmission.
引用
收藏
页码：3794 / 3799
页数：6
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