Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus

被引：42

作者：

Schrauwen, Eefje J. A. ^{[1
]}

Richard, Mathilde ^{[1
]}

Burke, David F. ^{[2
]}

Rimmelzwaan, Guus F. ^{[1
]}

Herfst, Sander ^{[1
]}

Fouchier, Ron A. M. ^{[1
]}

机构：

[1] Erasmus MC, Postgrad Sch Mol Med, Dept Virosci, Rotterdam, Netherlands

[2] Univ Cambridge, Dept Zool, Cambridge, England

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 07期

关键词：

UPPER RESPIRATORY-TRACT; AIRBORNE TRANSMISSION; A VIRUS; A/H5N1; VIRUS; H5; HA; FERRETS; PH; DROPLET; PATHOGENESIS; REPLICATION;

D O I：

10.1128/JVI.03052-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Receptor-binding preference and stability of hemagglutinin have been implicated as crucial determinants of airborne transmission of influenza viruses. Here, amino acid substitutions previously identified to affect these traits were tested in the context of an A/H7N9 virus. Some combinations of substitutions, most notably G219S and K58I, resulted in relatively high affinity for alpha 2,6-linked sialic acid receptor and acid and temperature stability. Thus, the hemagglutinin of the A/H7N9 virus may adopt traits associated with airborne transmission.

引用

页码：3794 / 3799

页数：6

共 50 条

[1] Glycan Receptor Binding of the Influenza A Virus H7N9 Hemagglutinin
Tharakaraman, Kannan
Jayaraman, Akila
Raman, Rahul
Viswanathan, Karthik
Stebbins, Nathan W.
Johnson, David
Shriver, Zachary
Sasisekharan, V.
Sasisekharan, Ram
CELL, 2013, 153 (07) : 1486 - 1493
[2] Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains
Zhang, Ting
Du, Haiwei
Guo, Li
Liu, Feng
Su, Haoxiang
Yang, Fan
VIROLOGY JOURNAL, 2021, 18 (01)
[3] Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains
Ting Zhang
Haiwei Du
Li Guo
Feng Liu
Haoxiang Su
Fan Yang
Virology Journal, 18
[4] Antigenic Drift of Influenza A(H7N9) Virus Hemagglutinin
Ning, Tingting
Nie, Jianhui
Huang, Weijin
Li, Changgui
Li, Xuguang
Liu, Qiang
Zhao, Hui
Wang, Youchun
JOURNAL OF INFECTIOUS DISEASES, 2019, 219 (01): : 19 - 25
[5] Role of Neuraminidase in Influenza A(H7N9) Virus Receptor Binding
Benton, Donald J.
Wharton, Stephen A.
Martin, Stephen R.
McCauley, John W.
JOURNAL OF VIROLOGY, 2017, 91 (11)
[6] Receptor binding by an H7N9 influenza virus from humans
Xiong, Xiaoli
Martin, Stephen R.
Haire, Lesley F.
Wharton, Stephen A.
Daniels, Rodney S.
Bennett, Michael S.
McCauley, John W.
Collins, Patrick J.
Walker, Philip A.
Skehel, John J.
Gamblin, Steven J.
NATURE, 2013, 499 (7459) : 496 - +
[7] Receptor binding by an H7N9 influenza virus from humans
Xiaoli Xiong
Stephen R. Martin
Lesley F. Haire
Stephen A. Wharton
Rodney S. Daniels
Michael S. Bennett
John W. McCauley
Patrick J. Collins
Philip A. Walker
John J. Skehel
Steven J. Gamblin
Nature, 2013, 499 : 496 - 499
[8] Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin
Xu, Ying
Peng, Ruchao
Zhang, Wei
Qi, Jianxun
Song, Hao
Liu, Sheng
Wang, Haiyuan
Wang, Min
Xiao, Haixia
Fu, Lifeng
Fan, Zheng
Bi, Yuhai
Yan, Jinghua
Shi, Yi
Gao, George F.
CELL REPORTS, 2019, 29 (08): : 2217 - +
[9] Adaptive amino acid substitutions enhance the virulence of a novel human H7N9 influenza virus in mice
Zhao, Yongkun
Yu, Zhijun
Liu, Linna
Wang, Tiecheng
Sun, Weiyang
Wang, Chengyu
Xia, Zhiping
Gao, Yuwei
Zhou, Bo
Qian, Jun
Xia, Xianzhu
VETERINARY MICROBIOLOGY, 2016, 187 : 8 - 14
[10] Amino Acid Residue 217 in the Hemagglutinin Glycoprotein Is a Key Mediator of Avian Influenza H7N9 Virus Antigenicity
Chang, Pengxiang
Sealy, Joshua E.
Sadeyen, Jean-Remy
Iqbal, Munir
JOURNAL OF VIROLOGY, 2019, 93 (01)

← 1 2 3 4 5 →