Effect of 1,25-dihydroxy vitamin D3 on toll-like receptor gene expression in neutrophils of pulmonary tuberculosis

被引：0
|
作者：
Harishankar, M. [1 ]
Afsal, K. [1 ]
Meenakshi, N. [2 ]
Selvaraj, P. [1 ]
机构：
[1] Indian Council Med Res, Natl Inst Res TB, Dept Immunol, TB Res Ctr, Madras 600031, Tamil Nadu, India
[2] Inst Thorac Med, Madras 600031, Tamil Nadu, India
来源：
CURRENT SCIENCE | 2014年 / 107卷 / 04期
关键词：
Gene expression; neutrophils; tuberculosis; toll-like receptors; MYCOBACTERIUM-TUBERCULOSIS; AUTOPHAGY; ACTIVATION; TLR2;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We studied the effect of 1,25-dihydroxy vitamin D-3 [1,25(OH)(2)D-3] on toll-like receptor (TLR) gene expression in neutrophils cultured with Mycobacterium tuberculosis (Mtb) with or without 1,25(OH)(2)D-3 in pulmonary tuberculosis patients and healthy controls. 1,25(OH)(2)D-3 significantly increased the expression of TLR2, TLR9 and TIRAP genes compared to control cells in both the study groups (P < 0.05). In healthy controls, a significantly upregulated expression of TIRAP was observed in Mtb infected cells cultured with 1,25(OH)(2)D-3 compared to Mtb infected cells alone (P < 0.05). In conclusion, 1,25(OH)(2)D-3 upregulated the expression of TLR and TIRAP genes, which could lead to the activation of TLR signalling pathways and augment the innate immunity to tuberculosis.
引用
收藏
页码：642 / 645
页数：4
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