Postmortem Findings for 7 Neonates with Congenital Zika Virus Infection

被引：39

作者：

Sousa, Anastacio Q. ^{[1
]}

Cavalcante, Diane I. M. ^{[1
]}

Franco, Luciano M. ^{[1
,2
]}

Araujo, Fernanda M. C. ^{[3
]}

Sousa, Emlia T. ^{[1
,2
]}

Valenca-Junior, Jose Telmo ^{[1
,2
]}

Rolim, Dionne B. ^{[4
,5
]}

Melo, Maria E. L. ^{[3
]}

Sindeaux, Pedro D. T. ^{[1
]}

Araujo, Marialva T. F. ^{[6
]}

Pearson, Richard D. ^{[7
]}

Wilson, Mary E. ^{[8
,9
]}

Pompeu, Margarida M. L. ^{[1
]}

机构：

[1] Univ Fed Ceara, Fortaleza, Ceara, Brazil

[2] Serv Verificacao Obitos SVO, Fortaleza, Ceara, Brazil

[3] Ceara State Cent Publ Hlth Lab, Fortaleza, Ceara, Brazil

[4] Univ Fortaleza, Fortaleza, Ceara, Brazil

[5] Ceara State Secretariat Hlth, Fortaleza, Ceara, Brazil

[6] Evandro Chagas Inst, Belem, Para, Brazil

[7] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA

[8] Univ Calif San Francisco, San Francisco, CA 94143 USA

[9] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

来源：

EMERGING INFECTIOUS DISEASES | 2017年 / 23卷 / 07期

关键词：

DENGUE; ANTIGEN;

D O I：

10.3201/eid2307.162019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Postmortem examination of 7 neonates with congenital Zika virus infection in Brazil revealed microcephaly, ventriculomegaly, dystrophic calcifications, and severe cortical neuronal depletion in all and arthrogryposis in 6. Other findings were leptomeningeal and brain parenchymal inflammation and pulmonary hypoplasia and lymphocytic infiltration in liver and lungs. Findings confirmed virus neurotropism and multiple organ infection.

引用

页码：1164 / 1167

页数：4

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