Is Tailored Adjuvant Treatment for Colon Cancer Possible?

被引：1
|
作者：
Van den Eynde, Marc [1 ]
Awada, Ahmad [1 ]
Hendlisz, Alain [1 ]
机构：
[1] Univ Libre Bruxelles, Med Oncol Unit, Dept Med, Inst Jules Bordet, B-1000 Brussels, Belgium
来源：
CLINICAL COLORECTAL CANCER | 2010年 / 9卷 / 01期
关键词：
5-Fluorouracil; Loss of heterozygosity; Microsatellite instability; Mismatch repair; Prognostic markers; METASTATIC COLORECTAL-CANCER; DNA MISMATCH REPAIR; TUMOR MICROSATELLITE-INSTABILITY; SOUTHWEST-ONCOLOGY-GROUP; RISK STAGE-II; RANDOMIZED-TRIAL; PHASE-III; INFILTRATING LYMPHOCYTES; PROGNOSTIC-SIGNIFICANCE; EXPRESSION PROFILES;
D O I：
10.3816/CCC.2010.n.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High-risk stage II and stage III colon cancers are associated with significant recurrence rates after surgical resection. Adjuvant chemotherapy has demonstrated a significant disease-free and overall survival benefit for patients, even if not helpful for all. Currently, there are limited clinical and molecular markers that can predict response to chemotherapy and clinical outcome in advanced colon cancer. Herein, we review and discuss recent data about the most promising clinicopathologic and molecular factors described thus far and that are of interest in the management of patients with colon cancer.
引用
收藏
页码：15 / 21
页数：7
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