Thiol-mediated free radical cyclisations of isocyanides on solid support

被引：11
|
作者：
Lamberto, M
Corbett, DF
Kilburn, JD [1 ]
机构：
[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 46期
关键词：
D O I：
10.1016/j.tetlet.2004.09.078
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three novel polymer-supported isocyanides have been synthesised, from commercial Wang and HMBA-AM resins, and reacted under radical conditions with 2-mercaptoethanol and ethanethiol to give the corresponding pyrrolidine or pyroglutamic acid derivatives in good yields. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8541 / 8543
页数：3
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