Studies on the cyclization reaction of D-aspartic acid

被引：1
|
作者：
Li, Yu Chuan [1 ]
Pang, Si Ping [1 ]
Yu, Yong Zhong [1 ]
机构：
[1] Beijing Inst Technol, Sch Life Sci & Technol, Beijing 100083, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 05期
基金：
中国国家自然科学基金;
关键词：
D-aspartic acid; cyclization reaction; azetidine-2-ones; 3,6-disubstituted piperazine-2,5-diones;
D O I：
10.1016/j.cclet.2007.03.013
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The cyclization reaction of D-aspartic acid was studied, the carboxyl groups of D-aspartic acid were protected by benzyl alcohol to give compound D-dibenzyl aspartate. Then (4R)-benzyl azetidine-2-one-4-carboxylate and meso-3,6-disubstituted piperazine2,5-diones were synthesized via intramolecular cyclization and intermolecular cyclization of D-dibenzyl aspartate, respectively, and their structures were confirmed by H-1 NMR and MS. Both cyclization reaction conditions were also investigated in detail. (c) 2007 Si Ping Pang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：516 / 518
页数：3
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