Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals

被引：13

作者：

Finch, JW

Toerne, KA

Schram, KH

Denton, MB ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] Waters Corp, Milford, MA 01757 USA

[3] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2005年 / 19卷 / 01期

关键词：

D O I：

10.1002/rcm.1742

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A photoionization hydrogen laser time-of-flight mass spectrometer system (H-2-TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2-TOFMS showed primarily intact molecular ions (M+) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid-phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：15 / 22

页数：8

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