Solid-Phase Organic Synthesis of 1,4-N-Vinyl- and 1,4-N-Allyl-Triazoles with the Sulfonate Linker

被引：6

作者：

He, Aiying

Sheng, Shouri ^{[1
]}

Huang, Zhenzhong

Liu, Li

Cai, Mingzhong

机构：

[1] Jiangxi Normal Univ, Inst Chem, Nanchang 330022, Jiangxi, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 06期

基金：

中国国家自然科学基金;

关键词：

1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; CLICK CHEMISTRY; REGIOSELECTIVE SYNTHESIS; SODIUM BENZENESULFINATE; CYCLOADDITION; AZIDES; HETEROCYCLES; SUPPORT;

D O I：

10.1002/jhet.1857

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polymer-supported 2-azidoethyl sulfonate and 3-azidopropyl sulfonate reagents have been developed and applied to the solid-phase organic synthesis of 1-vinyl- and 1-allyl-1,2,3-triazoles, respectively, by CuI-mediated azide-alkyne cycloadditions and subsequent cleavage from the polymer support through elimination reaction promoted by DBU. The advantages of this new synthetic method include simple operation and high yield of the products, as well as good stability of the reagents.

引用

页码：1862 / 1865

页数：4

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