Gene Editing of CCR5 in Hematopoietic Stem Cells in a Nonhuman Primate Model of HIV/AIDS

被引：1
|
作者：
Peterson, Christopher W. [1 ]
Wang, Jianbin [2 ]
Polacino, Patricia [3 ]
Holmes, Michael C. [2 ]
Hu, Shiu-Lok [3 ,4 ]
Gregory, Philip D. [2 ]
Kiem, Hans-Peter [1 ,5 ]
机构：
[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
[2] Sangamo BioSci Inc, Richmond, CA USA
[3] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA
[4] Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA
[5] Univ Washington, Seattle, WA 98195 USA
来源：
BLOOD | 2014年 / 124卷 / 21期
关键词：
D O I：
10.1182/blood.V124.21.4802.4802
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [31] Pleiotropy Complicates Human Gene Editing: CCR5Δ32 and Beyond
    Li, Ting
    Shen, Xia
    [J]. FRONTIERS IN GENETICS, 2019, 10
  • [32] Eradication of HIV by Transplantation of CCR5-Deficient Hematopoietic Stem Cells
    Huetter, Gero
    Ganepola, Susanne
    [J]. THESCIENTIFICWORLDJOURNAL, 2011, 11 : 1068 - 1076
  • [33] Electroporation of ZFN mRNA Enables Efficient CCR5 Gene Disruption in Mobilized Blood Hematopoietic Stem Cells at Clinical Scale
    Cannon, Paula M.
    Henley, Jill E.
    Wood, Travis
    Lynn Truong
    Wang, Jianbin
    Kim, Kenneth
    Yan, Jenny
    Gregory, Philip D.
    Lee, Gary
    Holmes, Michael C.
    [J]. MOLECULAR THERAPY, 2013, 21 : S71 - S72
  • [34] Targeting CCR5 Attenuates the Development of CAV in a Primate Model.
    Stoddard, Tiffany A.
    Kelishadi, Sean
    Zhang, Tianshu
    Avon, Christopher
    Welty, Emily
    Laaris, Amal
    Cheng, Xiangfei
    Berson, Amy
    Sung, Man-Ling
    Vu, Minh Diem
    Borie, Dominic C.
    Lora, Jose M.
    Auer, Johannes
    Dabbagh, Karim
    Azimzadeh, Agnes
    Pierson, Richard N., III
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 : 308 - 308
  • [35] CCR5 as target for HIV-1 gene therapy
    Nazari, Reza
    Joshi, Sadhna
    [J]. CURRENT GENE THERAPY, 2008, 8 (04) : 264 - 272
  • [36] Transient In Vivo β-Globin Production After Lentiviral Gene Transfer to Hematopoietic Stem Cells in the Nonhuman Primate
    Hayakawa, Jun
    Ueda, Takahiro
    Lisowski, Leszek
    Hsieh, Matthew M.
    Washington, Kareem
    Phang, Oswald
    Metzger, Mark
    Krouse, Allen
    Donahue, Robert E.
    Sadelain, Michel
    Tisdale, John F.
    [J]. HUMAN GENE THERAPY, 2009, 20 (06) : 563 - 572
  • [37] Antiretrovirals to CCR5 CRISPR/Cas9 gene editing - A paradigm shift chasing an HIV cure
    Khan, Amber
    Paneerselvam, Nandagopal
    Lawson, Brian R.
    [J]. CLINICAL IMMUNOLOGY, 2023, 255
  • [38] CCR5 Positive Cell Specific Targeted Transduction of a CCR5 shRNA Lentiviral Vector for HIV Gene Therapy
    Anderson, Joseph S.
    Nolta, Jan
    Bauer, Gerhard
    [J]. MOLECULAR THERAPY, 2009, 17 : S31 - S32
  • [39] Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice
    Myburgh, Renier
    Ivic, Sandra
    Pepper, Michael S.
    Gers-Huber, Gustavo
    Li, Duo
    Audige, Annette
    Rochat, Mary-Aude
    Jaquet, Vincent
    Regenass, Stephan
    Manz, Markus G.
    Salmon, Patrick
    Krause, Karl-Heinz
    Speck, Roberto F.
    [J]. JOURNAL OF VIROLOGY, 2015, 89 (13) : 6761 - 6772
  • [40] Gene transfer into hematopoietic stem cells of nonhuman primates
    vanBeusechem, VW
    Valerio, D
    [J]. HUMAN GENE THERAPY, 1996, 7 (14) : 1649 - 1668
12345