Cloning and expression of the chicken 25-hydroxyvitamin D3 24-hydroxylase cDNA

被引：4
|
作者：
Jehan, F [1 ]
Ismail, R [1 ]
Hanson, K [1 ]
DeLuca, HF [1 ]
机构：
[1] Univ Wisconsin, Coll Agr & Life Sci, Dept Biochem, Madison, WI 53706 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1395卷 / 03期
关键词：
vitamin D metabolism; cytochrome P-450; vitamin D hydroxylase; CYP24; cDNA cloning; cDNA expression;
D O I：
10.1016/S0167-4781(97)00177-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using a cDNA probe from the rat 24-hydrovitamin D-3 24-hydroxylase, the chicken 25-hydroxyvitamin D-3 24-hydroxylase cDNA has been isolated from a chicken kidney lambda gt11 library. The high degree of similarity with the mammalian 24-hydroxylase cDNAs strongly supports the belief that it is the chicken 25-hydroxyvitamin D-3 24-hydroxylase cDNA. The deduced amino acid sequences are also very well conserved and 325 of them are identical among the four known 25-hydroxyvitamin D-3 24-hydroxylases. This cDNA expressed in E. coli produces 24-hydroxylase activity. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：259 / 265
页数：7
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