Cloning and expression of the chicken 25-hydroxyvitamin D3 24-hydroxylase cDNA

被引：4

作者：

Jehan, F ^{[1
]}

Ismail, R ^{[1
]}

Hanson, K ^{[1
]}

DeLuca, HF ^{[1
]}

机构：

[1] Univ Wisconsin, Coll Agr & Life Sci, Dept Biochem, Madison, WI 53706 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1395卷 / 03期

关键词：

vitamin D metabolism; cytochrome P-450; vitamin D hydroxylase; CYP24; cDNA cloning; cDNA expression;

D O I：

10.1016/S0167-4781(97)00177-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using a cDNA probe from the rat 24-hydrovitamin D-3 24-hydroxylase, the chicken 25-hydroxyvitamin D-3 24-hydroxylase cDNA has been isolated from a chicken kidney lambda gt11 library. The high degree of similarity with the mammalian 24-hydroxylase cDNAs strongly supports the belief that it is the chicken 25-hydroxyvitamin D-3 24-hydroxylase cDNA. The deduced amino acid sequences are also very well conserved and 325 of them are identical among the four known 25-hydroxyvitamin D-3 24-hydroxylases. This cDNA expressed in E. coli produces 24-hydroxylase activity. (C) 1998 Elsevier Science B.V.

引用

页码：259 / 265

页数：7

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