PRDM9 points the zinc finger at meiotic recombination hotspots

被引：18
|
作者：
Neale, Matthew J. [1 ]
机构：
[1] Univ Sussex, MRC, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
来源：
GENOME BIOLOGY | 2010年 / 11卷 / 02期
基金：
英国医学研究理事会;
关键词：
INITIATION;
D O I：
10.1186/gb-2010-11-2-104
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Meiotic recombination events are spread nonrandomly across eukaryotic genomes in 'hotspots'. Recent work shows that a unique histone methyltransferase, PRDM9, determines their distribution.
引用
收藏
页数：3
相关论文
共 50 条
  • [1] PRDM9 points the zinc finger at meiotic recombination hotspots
    Matthew J Neale
    Genome Biology, 11
  • [2] Characterizing the zinc finger binding interactions of PRDM9 with the DNA of recombination hotspots
    Gravogl, Y.
    Schwarz, T.
    Tiemann-Boege, I.
    FEBS JOURNAL, 2014, 281 : 297 - 297
  • [3] The Case of the Fickle Fingers: How the PRDM9 Zinc Finger Protein Specifies Meiotic Recombination Hotspots in Humans
    Segurel, Laure
    Leffler, Ellen Miranda
    Przeworski, Molly
    PLOS BIOLOGY, 2011, 9 (12)
  • [4] Evolutionary dynamics of meiotic recombination hotspots regulator PRDM9 in bovids
    Ahlawat, Sonika
    De, Sachinandan
    Sharma, Priyanka
    Sharma, Rekha
    Arora, Reena
    Kataria, R. S.
    Datta, T. K.
    Singh, R. K.
    MOLECULAR GENETICS AND GENOMICS, 2017, 292 (01) : 117 - 131
  • [5] Evolutionary dynamics of meiotic recombination hotspots regulator PRDM9 in bovids
    Sonika Ahlawat
    Sachinandan De
    Priyanka Sharma
    Rekha Sharma
    Reena Arora
    R. S. Kataria
    T. K. Datta
    R. K. Singh
    Molecular Genetics and Genomics, 2017, 292 : 117 - 131
  • [6] PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice
    Baudat, F.
    Buard, J.
    Grey, C.
    Fledel-Alon, A.
    Ober, C.
    Przeworski, M.
    Coop, G.
    de Massy, B.
    SCIENCE, 2010, 327 (5967) : 836 - 840
  • [7] PRDM9 and the evolution of recombination hotspots
    Ubeda, Francisco
    Russell, Timothy W.
    Jansen, Vincent A. A.
    THEORETICAL POPULATION BIOLOGY, 2019, 126 : 19 - 32
  • [8] The Function of PRDM9 on Mammalian Recombination Hotspots
    Guo Xiao-Qiang
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2010, 37 (09) : 929 - 931
  • [9] Meiosis: A PRDM9 Guide to the Hotspots of Recombination
    Hochwagen, Andreas
    Marais, Gabriel A. B.
    CURRENT BIOLOGY, 2010, 20 (06) : R271 - R274
  • [10] Prdm9, a key control of mammalian recombination hotspots
    Baudat, Frederic
    Buard, Jerome
    Grey, Corinne
    de Massy, Bernard
    M S-MEDECINE SCIENCES, 2010, 26 (05): : 468 - 470
12345