Peanut Allergy: New Developments and Clinical Implications

被引:2
|
作者
Commins, Scott P. [1 ,2 ,3 ,4 ]
Kim, Edwin H. [1 ,2 ,3 ]
Orgel, Kelly [3 ]
Kulis, Mike [3 ]
机构
[1] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27599 USA
[2] Thurston Arthrit Res Ctr, Chapel Hill, NC USA
[3] Univ N Carolina, Sch Med, Dept Pediat, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Dept Med, Div Rheumatol Allergy & Immunol, 3300 Thurston Bldg,CB 7280, Chapel Hill, NC 27599 USA
关键词
Peanut allergy; IgE; Anaphylaxis; Food allergy; ORAL IMMUNOTHERAPY; EPICUTANEOUS IMMUNOTHERAPY; DOUBLE-BLIND; DESENSITIZATION; SAFETY; TRIAL; RISK;
D O I
10.1007/s11882-016-0613-x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Food allergies have increased in prevalence over the past 20 years, now becoming an important public health concern. Although there are no therapies currently available for routine clinical care, recent reports have indicated that immunotherapies targeting the mucosal immune system may be effective. Oral immunotherapy is conducted by administering small, increasing amounts of food allergen; it has shown promise for desensitizing individuals with peanut, egg, or milk allergies. Sublingual immunotherapy also desensitizes allergic patients to foods-two major studies have examined the effects of sublingual immunotherapy in subjects with peanut allergies. We review the complex nature of IgE-mediated food allergies and the therapies being evaluated in clinical trials. We focus on the diagnosis and management of food allergies and investigational therapies.
引用
收藏
页数:6
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