In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla

被引：79
|
作者：
Edden, Richard A. E.
Pomper, Martin G.
Barker, Peter B.
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA
[3] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA
来源：
MAGNETIC RESONANCE IN MEDICINE | 2007年 / 57卷 / 06期
关键词：
NAA; NAAG; magnetic resonance spectroscopy; 3; Tesla; MEGA-PRESS;
D O I：
10.1002/mrm.21234
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A method is described that allows the in vivo differentiation of N-acetyl aspartate (NAA) from N-acetyl aspartyl glutamate (NAAG) by in vivo MR spectroscopy (MRS) at 3 Tesla (3T). The method, which is based on MEGA-point-resolved spectroscopy (PRESS) editing, selectively targets the aspartyl spin system of one species while deliberately removing the other species from the spectrum. This allows quantitative measurements of NAA and NAAG without the need for fitting of unresolved peaks. White matter concentrations of NAA (6.7 +/- 0.3 mM) and NAAG (2.2 +/- 0.3 mM) were measured in 10 healthy volunteers to demonstrate the method.
引用
收藏
页码：977 / 982
页数：6
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