Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes

被引：39
|
作者：
Gomez-Ruiz, Santiago [1 ]
Kaluderovic, Goran N.
Polo-Ceron, Dorian
Prashar, Sanjiv
Fajardo, Mariano
Zizak, Zejko
Juranic, Zorica D.
Sabo, Tibor J.
机构：
[1] Univ Rey Juan Carlos, ESCET, Dept Quim Inorgan & Analit, Madrid 28933, Spain
[2] Inst Chem Technol & Met, Dept Chem, Belgrade 11000, Serbia
[3] Inst Oncol & Radiol, Belgrade 11000, Serbia
[4] Univ Belgrade, Fac Chem, Belgrade 11001, Serbia
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2007年 / 10卷 / 07期
关键词：
ansa-titanocene compounds; antitumoural activity; adenocarcinoma HeLa; human myelogenous leukemia K562; human malignant melanoma Fem-x;
D O I：
10.1016/j.inoche.2007.03.016
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me{(CH2=CH)Si(eta(5)-Me-5(4)) (eta(5)-C5H4))Cl-2] (1), [Ti{Me(H)Si(eta(5)-C5Me4)(2)}Cl-2] (2), [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (3) and [Ti{Me2Si(eta(5)-C5Me4)(eta(5)-C5H3(CMe2(CH2CH2CH=CH2)))}Cl-2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：748 / 752
页数：5
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