Current Strategies to Enhance Anti-Tumour Immunity

被引：12
|
作者：
Cook, Katherine W. [1 ]
Durrant, Lindy G. [1 ,2 ]
Brentville, Victoria A. [1 ]
机构：
[1] Univ Nottingham, Acad Dept Clin Oncol, Scancell Ltd, City Hosp Campus, Nottingham NG5 1PB, Notts, England
[2] Univ Nottingham, Acad Dept Clin Oncol, Sch Med, Div Canc & Stem Cells, City Hosp Campus, Nottingham NG5 1PB, Notts, England
来源：
BIOMEDICINES | 2018年 / 6卷 / 02期
基金：
英国医学研究理事会;
关键词：
vaccination; oncolytic viruses; adoptive cell transfer; checkpoint inhibition; immune modulators; immune surveillance; REGULATORY T-CELLS; TUMOR-ASSOCIATED ANTIGENS; ONCOLYTIC VIRUS THERAPY; PHASE-I TRIAL; HUMAN-MELANOMA; SUPPRESSOR-CELLS; INDOLEAMINE 2,3-DIOXYGENASE; RESTRICTED PHOSPHOPEPTIDES; ANTI-CTLA-4; THERAPY; CANCER REGRESSION;
D O I：
10.3390/biomedicines6020037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The interaction of the immune system with cancer is complex, but new approaches are resulting in exciting therapeutic benefits. In order to enhance the immune response to cancer, immune therapies seek to either induce high avidity immune responses to tumour specific antigens or to convert the tumour to a more pro-inflammatory microenvironment. Strategies, including vaccination, oncolytic viruses, and adoptive cell transfer all seek to induce anti-tumour immunity. To overcome the suppressive tumour microenvironment checkpoint inhibitors and modulators of regulatory cell populations have been investigated. This review summarizes the recent advances in immune therapies and discusses the importance of combination therapies in the treatment of cancers.
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收藏
页数：22
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