Development of a multi-modal sensor for in vivo monitoring of tumor oxygen dynamics

被引:0
|
作者
Qiang, Bo [1 ]
Cao, Xianhua [3 ]
Sun, Duxin [3 ]
He, Guanglong [2 ]
Zweier, Jay [2 ]
Xu, Ronald [1 ]
机构
[1] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA
[2] Ohio State Univ, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA
[3] Ohio State Univ, Div Pharmaceut, Coll Pharm, Columbus, OH 43210 USA
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中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
A multi-modal sensor has been developed for noninvasive, real time, in vivo monitoring of oxygen intake, consumption and blood flow dynamics in tumor tissue during ischemia-reperfusion. The sensor head integrated a near infrared tissue oximeter for tissue oxygen saturation and hemoglobin concentration measurement, a laser Doppler for blood flow measurement, and an electron paramagnetic resonance spectroscope (EPRS) for oxygen tension measurement. The sensor has been tested on athymic NU/NU mice with xenograft pancreatic cancer implanted on right legs. Ischemia-reperfusion was introduced by physical ligation of the femur artery. Preliminary results demonstrated technical feasibility of simultaneous tissue oxygen and blood flow measurements. Further data analysis is on the way.
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页码:249 / 249
页数:1
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