Development of a multi-modal sensor for in vivo monitoring of tumor oxygen dynamics

被引：0
|
作者：
Qiang, Bo [1 ]
Cao, Xianhua [3 ]
Sun, Duxin [3 ]
He, Guanglong [2 ]
Zweier, Jay [2 ]
Xu, Ronald [1 ]
机构：
[1] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA
[2] Ohio State Univ, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA
[3] Ohio State Univ, Div Pharmaceut, Coll Pharm, Columbus, OH 43210 USA
来源：
CONFERENCE DIGEST OF THE 2006 JOINT 31ST INTERNATIONAL CONFERENCE ON INFRARED AND MILLIMETER WAVES AND 14TH INTERNATIONAL CONFERENCE ON TERAHERTZ ELECTRONICS | 2006年
关键词：
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
A multi-modal sensor has been developed for noninvasive, real time, in vivo monitoring of oxygen intake, consumption and blood flow dynamics in tumor tissue during ischemia-reperfusion. The sensor head integrated a near infrared tissue oximeter for tissue oxygen saturation and hemoglobin concentration measurement, a laser Doppler for blood flow measurement, and an electron paramagnetic resonance spectroscope (EPRS) for oxygen tension measurement. The sensor has been tested on athymic NU/NU mice with xenograft pancreatic cancer implanted on right legs. Ischemia-reperfusion was introduced by physical ligation of the femur artery. Preliminary results demonstrated technical feasibility of simultaneous tissue oxygen and blood flow measurements. Further data analysis is on the way.
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页码：249 / 249
页数：1
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