The simplicity of complex MACs

被引：20
|
作者：
Vos, JMH [1 ]
机构：
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
来源：
NATURE BIOTECHNOLOGY | 1997年 / 15卷 / 12期
关键词：
episome; gene therapy; centromere; viral vector; transgenesis;
D O I：
10.1038/nbt1197-1257
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The development of mammalian artificial chromosomes (MACs) would be useful for biotechnology and biomedicine, including their use in functional genomics, transgenic animals and gene therapy. By analogy to large cloning systems in microorganisms, MACs may be engineered using endogenous chromosomal elements such as the yeast-based artificial chromosomes (YACs), or exogenous extra-chromosomal components derived from viruses and other cellular parasites such as the bacterial-based artificial chromosomes (BACs) and pi artificial chromosomes (PACs).
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页码：1257 / 1259
页数：3
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