Isoprenoid intermediates in the cholesterol pathway determine the fate of pathogenic T cells during CNS autoimmunity

被引：0
|
作者：
Youssef, S.
Dunn, S. E.
Zamvil, S. S.
Steinman, L.
机构：
[1] Stanford Univ, Stanford, CA 94305 USA
[2] Univ Calif San Francisco, San Francisco, CA 94143 USA
来源：
MULTIPLE SCLEROSIS | 2007年 / 13卷 / 02期
关键词：
atorvastatin; EAE; farnesyl-pyrophosphate; geranylgeranyl-pyrophosphate; HMG-CoA reductase; Th1/Th2;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：298 / 299
页数：2
相关论文
共 50 条
  • [21] IL-3 Is a Marker of Encephalitogenic T Cells, but Not Essential for CNS Autoimmunity
    Lee, Priscilla W.
    Xin, Matthew K.
    Pei, Wei
    Yang, Yuhong
    Lovett-Racke, Amy E.
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [22] Tanshinone IIA Ameliorates CNS Autoimmunity by Promoting the Differentiation of Regulatory T Cells
    Gong, Ye
    Liu, Yuan-Chu
    Ding, Xiao-Li
    Fu, Ying
    Cui, Lang-Jun
    Yan, Ya-Ping
    NEUROTHERAPEUTICS, 2020, 17 (02) : 690 - 703
  • [23] PIP3 pathway in regulatory T cells and autoimmunity
    Kashiwada, Masaki
    Lu, Ping
    Rothman, Paul B.
    IMMUNOLOGIC RESEARCH, 2007, 39 (1-3) : 194 - 224
  • [24] PIP3 pathway in regulatory T cells and autoimmunity
    Masaki Kashiwada
    Ping Lu
    Paul B. Rothman
    Immunologic Research, 2007, 39 : 194 - 224
  • [25] Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
    Schnell, Alexandra
    Huang, Linglin
    Singer, Meromit
    Singaraju, Anvita
    Barilla, Rocky M.
    Regan, Brianna M. L.
    Bollhagen, Alina
    Thakore, Pratiksha, I
    Dionne, Danielle
    Delorey, Toni M.
    Pawlak, Mathias
    zu Horste, Gerd Meyer
    Rozenblatt-Rosen, Orit
    Irizarry, Rafael A.
    Regev, Aviv
    Kuchroo, Vijay K.
    CELL, 2021, 184 (26) : 6281 - +
  • [26] Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4
    Simon Glatigny
    Rebekka Duhen
    Carlos Arbelaez
    Swarnima Kumari
    Estelle Bettelli
    Scientific Reports, 5
  • [27] Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4
    Glatigny, Simon
    Duhen, Rebekka
    Arbelaez, Carlos
    Kumari, Swarnima
    Bettelli, Estelle
    SCIENTIFIC REPORTS, 2015, 5
  • [28] Fate decisions in forebrain progenitor cells during development and in CNS injury
    Rowitch, David H.
    NEURON GLIA BIOLOGY, 2007, 2 : S21 - S21
  • [29] Cutting edge:: Human γδ T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis
    Altincicek, B
    Moll, J
    Campos, N
    Foerster, G
    Beck, E
    Hoeffler, JF
    Grosdemange-Billiard, C
    Rodríguez-Concepción, M
    Rohmer, M
    Boronat, A
    Eberl, M
    Jomaa, H
    JOURNAL OF IMMUNOLOGY, 2001, 166 (06): : 3655 - 3658
  • [30] IRF4 deficiency in T cells leads to increased production of IFNg in T cells and resistance to CNS autoimmunity
    Mufazalov, I. A.
    Kuschmann, J.
    Nikolaev, A.
    Yogev, N.
    Reissig, S.
    Bopp, T.
    Klein, U.
    Waisman, A.
    IMMUNOLOGY, 2012, 137 : 7 - 7
12345