Perspective: The insulin signaling system - A common link in the pathogenesis of type 2 diabetes

被引：107
|
作者：
Withers, DJ
White, M
机构：
[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Howard Hughes Med Inst, Boston, MA 02215 USA
[2] Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Metab Med, London W12 0NN, England
来源：
ENDOCRINOLOGY | 2000年 / 141卷 / 06期
关键词：
D O I：
10.1210/en.141.6.1917
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1917 / 1921
页数：5
相关论文
共 50 条
  • [31] Loss of Pulsatile Insulin Secretion: A Factor in the Pathogenesis of Type 2 Diabetes?
    Wahren, John
    Kallas, Asa
    [J]. DIABETES, 2012, 61 (09) : 2228 - 2229
  • [32] Intertissue communication in the pathogenesis of insulin resistance in obesity and type 2 diabetes
    Kahn, BB
    [J]. FASEB JOURNAL, 2006, 20 (05): : A1335 - A1335
  • [33] Defects in Insulin Secretion and Action in the Pathogenesis of Type 2 Diabetes Mellitus
    Devjit Tripathy
    Alberto O. Chavez
    [J]. Current Diabetes Reports, 2010, 10 : 184 - 191
  • [34] Treatment of Type 2 Diabetes through Hepatic Insulin Signaling
    Tao, Rongya
    Stohr, Oliver
    Copps, Kyle
    White, Morris F.
    [J]. DIABETES, 2016, 65 : A13 - A13
  • [35] Type 2 diabetes: Microbial metabolite impairs insulin signaling
    Crunkhorn S.
    [J]. Nature Reviews Drug Discovery, 2018, 17 (12) : 864 - 864
  • [36] Epigenetics The missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes
    Gilbert, Elizabeth R.
    Liu, Dongmin
    [J]. EPIGENETICS, 2012, 7 (08) : 841 - 852
  • [37] Molecular pathogenesis of type 2 diabetes via insulin signaling in membrane microdomains: involvement of ganglioside GM3
    Inokuchi, J
    [J]. GLYCOBIOLOGY, 2004, 14 (11) : 1063 - 1064
  • [38] Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
    Mackenzie, Richard W. A.
    Elliott, Bradley T.
    [J]. DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2014, 7 : 55 - 64
  • [39] Contribution of abnormal insulin secretion and insulin resistance to the pathogenesis of type 2 diabetes in myotonic dystrophy
    Perseghin, G
    Caumo, A
    Arcelloni, C
    Benedini, S
    Lanzi, R
    Pagliato, E
    Sereni, LP
    Testolin, G
    Battezzati, A
    Comi, G
    Comola, M
    Luzi, L
    [J]. DIABETES CARE, 2003, 26 (07) : 2112 - 2118
  • [40] The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    Weyer, C
    Bogardus, C
    Mott, DM
    Pratley, RE
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (06): : 787 - 794
12345