The FANCM family of DNA helicases/translocases

被引：86
|
作者：
Whitby, Matthew C. [1 ]
机构：
[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England
来源：
DNA REPAIR | 2010年 / 9卷 / 03期
基金：
英国惠康基金;
关键词：
FANCM; Mph1; Fml1; Hef; Homologous recombination; Fanconi Anemia; ANEMIA CORE COMPLEX; HOMOLOGOUS RECOMBINATION; CELL-CYCLE; SACCHAROMYCES-CEREVISIAE; MONOUBIQUITINATED FANCD2; PROMOTES RECOMBINATION; REPLICATION FORKS; CROSSING-OVER; MPH1; GENE; PROTEIN;
D O I：
10.1016/j.dnarep.2009.12.012
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
FANCM and its relatives, Hef, Mph1 and Fml1, are DNA junction-specific helicases/translocases that target and process perturbed replication forks and intermediates of homologous recombination. They have variously been implicated in promoting the activation of the S-phase checkpoint, recruitment of the Fanconi Anemia Core Complex to sites of DNA damage, crossover avoidance during DNA double-strand break repair by homologous recombination, This review summarises our current understanding of the biochemical activities and biological functions and the replicative bypass of DNA lesions by template switching. of the FANCM family. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：224 / 236
页数：13
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