Spongian diterpenes from Chinese marine sponge Spongia officinalis

被引:20
|
作者
Han, Guan-Ying [1 ,2 ]
Sun, Dong-Yu [1 ,3 ]
Liang, Lin-Fu [1 ,5 ]
Yao, Li-Gong [1 ]
Chen, Kai-Xian [1 ,4 ]
Guo, Yue-Wei [1 ,4 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
[2] Jinzhou Med Univ, Affiliated Hosp 1, 2 Renmin Rd, Jinzhou 121001, Peoples R China
[3] Jinzhou Med Univ, Sch Pharmaceut Sci, Jinzhou 121001, Peoples R China
[4] Qingdao Natl Lab Marine Sci & Technol, Open Studio Drugabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
[5] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China
关键词
Spongia officinalis; Diterpene; 3-Nor-spongian; Absolute configuration; NATURAL-PRODUCTS; APLYSILLA-ROSEA; CONSTITUENTS; METABOLITES; DISCOVERY; MATAMATA;
D O I
10.1016/j.fitote.2018.02.010
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
3-Nor-spongiolide A (1), belonging to the extremely rare 3-nor-spongian carbon skeleton, and spongiolides A (2) and B (3), having gamma-butenolide instead of furan ring as usual for ring D, together with six related known metabolites were isolated from South China Sea sponge Spongia officinalis as its metabolic components. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of three new compounds 1-3 were determined by ECD calculations.
引用
收藏
页码:159 / 165
页数:7
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