A novel engineered peptide, a narrow-spectrum antibiotic, is effective against vancomycin-resistant Enterococcus faecalis

被引：32
|
作者：
Qiu, XQ
Zhang, H
Wang, H
Wu, GY
机构：
[1] Univ Connecticut, Ctr Hlth, Dept Med, Div Gastroenterol Hepatol, Farmington, CT 06030 USA
[2] W China Hosp, Lab Biomembrane & Membrane Prot, Chengdu, Peoples R China
[3] W China Second Univ Hosp, Genet Lab, Chengdu, Peoples R China
[4] Sichuan Univ, Chengdu 610064, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 03期
关键词：
D O I：
10.1128/AAC.49.3.1184-1189.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A novel antienterococcal peptide was prepared by fusing the enterococcal cCF10 pheromone to the channel-forming domain of colicin Ia, forming Enterococcus faecalis pheromonicin (PMC-EF). This peptide was bactericidal against vancomycin-resistant Enterococcus faecalis (VRE) organisms. Electron microscopy and vital dyes confirmed increased membrane permeability. All mice made bacteremic with VRE strains survived when they were treated with PMC-EF, while all controls died.
引用
收藏
页码：1184 / 1189
页数：6
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