A novel engineered peptide, a narrow-spectrum antibiotic, is effective against vancomycin-resistant Enterococcus faecalis

被引：32
|
作者：
Qiu, XQ
Zhang, H
Wang, H
Wu, GY
机构：
[1] Univ Connecticut, Ctr Hlth, Dept Med, Div Gastroenterol Hepatol, Farmington, CT 06030 USA
[2] W China Hosp, Lab Biomembrane & Membrane Prot, Chengdu, Peoples R China
[3] W China Second Univ Hosp, Genet Lab, Chengdu, Peoples R China
[4] Sichuan Univ, Chengdu 610064, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 03期
关键词：
D O I：
10.1128/AAC.49.3.1184-1189.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A novel antienterococcal peptide was prepared by fusing the enterococcal cCF10 pheromone to the channel-forming domain of colicin Ia, forming Enterococcus faecalis pheromonicin (PMC-EF). This peptide was bactericidal against vancomycin-resistant Enterococcus faecalis (VRE) organisms. Electron microscopy and vital dyes confirmed increased membrane permeability. All mice made bacteremic with VRE strains survived when they were treated with PMC-EF, while all controls died.
引用
收藏
页码：1184 / 1189
页数：6
相关论文
共 50 条
  • [1] Vancomycin-resistant Enterococcus faecalis
    Branley, J
    Yan, B
    Benn, RAV
    MEDICAL JOURNAL OF AUSTRALIA, 1996, 165 (05) : 292 - 292
  • [2] Vancomycin-resistant Enterococcus faecalis in Serbia
    Stosovic, B
    Stepanovic, S
    Donabedian, S
    Tosic, T
    Jovanovic, M
    EMERGING INFECTIOUS DISEASES, 2004, 10 (01) : 157 - 158
  • [3] Novel chromogenic medium for detection of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis
    Cuzon, Gaelle
    Naas, Thierry
    Fortineau, Nicolas
    Nordmann, Patrice
    JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (07) : 2442 - 2444
  • [4] A novel chromogenic medium for vancomycin-resistant Enterococcus faecium and Enterococcus faecalis detection
    Cuzon, G.
    Naas, T.
    Fortineau, N.
    Nordmann, P.
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2007, 29 : S22 - S22
  • [5] Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis
    Jiang, Yong-Wei
    Xu, Liang
    Fu, Wei
    Lin, Hua
    Yu, Jian-Ming
    Sun, Xun
    TETRAHEDRON, 2018, 74 (27) : 3527 - 3533
  • [6] Molecular and clinical epidemiology of vancomycin-resistant Enterococcus faecalis
    Oprea, SF
    Zaidi, N
    Donabedian, SM
    Balasubramaniam, M
    Hershberger, E
    Zervos, MJ
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 (04) : 626 - 630
  • [7] Altered peptidoglycan composition in vancomycin-resistant Enterococcus faecalis
    DeJonge, BLM
    Handwerger, S
    Gage, D
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (04) : 863 - 869
  • [8] Clinical isolation of vancomycin-resistant Enterococcus faecalis in Taiwan
    Ben, RJ
    Lu, JJ
    Young, TG
    Chi, WM
    Wang, CC
    Chu, ML
    Wang, JC
    JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 1996, 95 (12) : 946 - 949
  • [9] First case of vancomycin-resistant Enterococcus faecalis in Algeria
    Aggoune, N.
    Chabani, A.
    Tiouit, D.
    Naim, M.
    Rahal, K.
    MEDECINE ET MALADIES INFECTIEUSES, 2008, 38 (10): : 557 - 558
  • [10] β-Lactam combinations with daptomycin provide synergy against vancomycin-resistant Enterococcus faecalis and Enterococcus faecium
    Smith, Jordan R.
    Barber, Katie E.
    Raut, Animesh
    Aboutaleb, Mostafa
    Sakoulas, George
    Rybak, Michael J.
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015, 70 (06) : 1738 - 1743
12345