Synthesis of activated poly(α,β-malic acid) using N-hydroxysuccinimide and its gelation with collagen as biomaterials

被引：18

作者：

Kajiyama, T

Kobayashi, H

Taguchi, T

Saito, H

Kamatsu, Y

Kataoka, K

Tanaka, D

机构：

[1] Kanazawa Inst Technol, Coll Environm Engn & Architecture, Dept Environm Chem, Nonoichi, Ishikawa 9218501, Japan

[2] Natl Inst Mat Sci, Ctr Biomat, Tsukuba, Ibaraki 3050044, Japan

[3] Furuuchi Chem Corp, Shinagawa Ku, Tokyo 1400013, Japan

[4] Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2004年 / 24卷 / 6-8期

关键词：

poly(alpha; beta-malic acid); collagen; gel; N-hydroxysuccinimide; water-soluble polymer; cross-linker;

D O I：

10.1016/j.msec.2004.08.023

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The development of synthetic biodegradable polymers, such as poly(alpha-hydroxy acid), is particularly important for constructing medical devices, including scaffolds and sutures, and has attracted growing interest in the biomedical field. Here, we report a synthesis method for activated polymalic acid (Su-PMA) by the reaction between synthesized alpha,beta-PMA and N-hydroxysuccinimide (HOSu) in the presence of 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride (EDC), and present an evaluation of the gelation properties of Su-PMA with collagen. The Su content of the resulting Su-PMA is higher than the feed ratio. Su content and chain length of Su-PMA influence gelation properties, as Su-PMA with low Su content formed a gel. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：815 / 819

页数：5

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