Neuroprotective triterpene saponins from the leaves of Panax notoginseng

被引：32
|
作者：
Huang, Ji-Wu [1 ,2 ]
Du, Yi-Qian [1 ,2 ]
Li, Chuang-Jun [1 ,2 ]
Yang, Jing-Zhi [1 ,2 ]
Ma, Jie [1 ,2 ]
Zang, Ying-Da [1 ,2 ]
Chen, Nai-Hong [1 ,2 ]
Zhang, Dong-Ming [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing, Peoples R China
[2] Peking Union Med Coll, Beijing, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Panax notoginseng leaves; triterpene saponins; neuroprotective;
D O I：
10.1080/14786419.2019.1677657
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new triterpene saponins, namely notoginsenoside Ng5 (1) and notoginsenoside Ng6 (2) were isolated from the leaves of Panax notoginseng, along with five known ones. Their structures were determined by chemical methods, NMR and X-ray experiments. The absolute configuration of compound 3 with four sugar units was confirmed by single crystal X-ray analysis. Compounds 2?4 and 6 inhibited PC12 cell damage induced by serum deprivation, and increased cell viability from 58.7???6.7% to 66.7???4.5%, 76.1???6.1%, 64.7???5.2% and 67.2???5.0% at 10??M, respectively.
引用
收藏
页码：2388 / 2394
页数：7
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