Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

被引：0
|
作者：
Qiu Xue-peng [1 ,2 ]
Kosobe, Toshiyuki [1 ]
Kawashima, Norimichi [1 ]
机构：
[1] Toin Univ Yokohama, Fac Biomed Engn, Aoba Ku, Yokohama, Kanagawa 2258502, Japan
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Polymer Engn, Changchun 130022, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2010年 / 26卷 / 01期
关键词：
Photodynamic therapy; Methanesulfonate salt; 5-Aminolevulinic acid; Derivative; Cancer cell; IN-VITRO; AMINOLEVULINIC-ACID; SKIN; HEXYLESTER; VIVO; BIODISTRIBUTION; METHYLESTER; PENETRATION; CARCINOMA; KINETICS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 5-aminolevulinic acid and its alkylester methanesulfonates was exploited to photodynamic therapy(PDT) of human lymphocytic cells, U-937 in vitro. The PDT efficiency is influenced by the concentration and incubation time. Generally, for ALA and its alkylester methanesulfonates, the cell survival rate decreases and the accumulation ability of PpIX increases with the concentration and incubation time. We found that the longer carbon chain methanesulfonates(C5-S, C6-S, C8-S) exhibit better PDT effect than ALA methanesulfonate. This possibly provides a promising route to the clinical application of PpIX-mediated PDT to cancer cell.
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页码：66 / 69
页数：4
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