Separation of cocaine stereoisomers by capillary electrophoresis using sulfated cyclodextrins

被引：6
|
作者：
Cabovska, B
Norman, AB
Stalcup, AM
机构：
[1] Univ Cincinnati, Dept Chem, Cincinnati, OH 45221 USA
[2] Univ Cincinnati, Coll Med, Dept Psychiat, Div Neurosci, Cincinnati, OH USA
来源：
ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2003年 / 376卷 / 01期
关键词：
capillary electrophoresis; sulfated cyclodextrins; cocaine stereoisomers; (-)-cocaine HCl; (+)-cocaine base; (-)-pseudococaine; (+)- pseudococaine;
D O I：
10.1007/s00216-003-1850-0
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A capillary electrophoretic method for the separation of cocaine and its stereoisomers was developed. In this study, the effect of organic modifier was also investigated. The separation was achieved using 1% sulfated cyclodextrin, 10 mmol L-1 phosphate buffer, 10% methanol at pH 3. The method provides good reproducibility and easy application.
引用
收藏
页码：134 / 137
页数：4
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