Separation of cocaine stereoisomers by capillary electrophoresis using sulfated cyclodextrins

被引：6
|
作者：
Cabovska, B
Norman, AB
Stalcup, AM
机构：
[1] Univ Cincinnati, Dept Chem, Cincinnati, OH 45221 USA
[2] Univ Cincinnati, Coll Med, Dept Psychiat, Div Neurosci, Cincinnati, OH USA
来源：
ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2003年 / 376卷 / 01期
关键词：
capillary electrophoresis; sulfated cyclodextrins; cocaine stereoisomers; (-)-cocaine HCl; (+)-cocaine base; (-)-pseudococaine; (+)- pseudococaine;
D O I：
10.1007/s00216-003-1850-0
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A capillary electrophoretic method for the separation of cocaine and its stereoisomers was developed. In this study, the effect of organic modifier was also investigated. The separation was achieved using 1% sulfated cyclodextrin, 10 mmol L-1 phosphate buffer, 10% methanol at pH 3. The method provides good reproducibility and easy application.
引用
收藏
页码：134 / 137
页数：4
相关论文
共 50 条
  • [1] Separation of cocaine stereoisomers by capillary electrophoresis using sulfated cyclodextrins
    B. Cabovska
    A. B. Norman
    A. M. Stalcup
    Analytical and Bioanalytical Chemistry, 2003, 376 : 134 - 137
  • [2] SEPARATION OF DRUG STEREOISOMERS BY CAPILLARY ELECTROPHORESIS WITH CYCLODEXTRINS
    PETERSON, TE
    JOURNAL OF CHROMATOGRAPHY, 1993, 630 (1-2): : 353 - 361
  • [3] Separation of hydroxynorketamine stereoisomers using capillary electrophoresis with sulfated β-cyclodextrin and highly sulfated γ-cyclodextrin
    Sandbaumhuter, Friederike A.
    Theurillat, Regula
    Thormann, Wolfgang
    ELECTROPHORESIS, 2017, 38 (15) : 1878 - 1885
  • [4] Enantiomer separation by capillary electrophoresis using highly sulfated cyclodextrins as a chiral selector
    Kuwahara, Y
    Izumoto, S
    Nishi, H
    BUNSEKI KAGAKU, 2001, 50 (01) : 69 - 77
  • [5] Molecular Modeling and Chiral Separation of Benzodiazepines by Capillary Electrophoresis Using Highly Sulfated Cyclodextrins
    Gabriela Vargas-Martinez, Maria
    Ramirez-Galicia, Guillermo
    JOURNAL OF THE MEXICAN CHEMICAL SOCIETY, 2018, 62 (02) : 358 - 370
  • [6] The separation of the enantiomers of diquats by capillary electrophoresis using randomly sulfated cyclodextrins as chiral selectors
    Bilek, Jan
    Koval, Dusan
    Sazelova, Petra
    Solinova, Veronika
    Severa, Lukas
    Gutierrez, Paul E. Reyes
    Teply, Filip
    Kasicka, Vaclav
    JOURNAL OF SEPARATION SCIENCE, 2023, 46 (18)
  • [7] Applications bf highly sulfated cyclodextrins for enantiomeric separation by capillary electrophoresis
    Chen, FTA
    Evangelista, RA
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1999, 46 (05) : 847 - 860
  • [8] Comparison of native, alkylated and charged cyclodextrins for the chiral separation of labetalol stereoisomers by capillary electrophoresis
    Le Potier, I
    Tamisier-Karolak, SL
    Morin, P
    Megel, F
    Taverna, M
    JOURNAL OF CHROMATOGRAPHY A, 1998, 829 (1-2) : 341 - 349
  • [9] Use of Sulfated Cyclofructan 6 and Sulfated Cyclodextrins for the Chiral Separation of Four Basic Pharmaceuticals by Capillary Electrophoresis
    Zhang, Yi Jun
    Huang, Ming Xian
    Zhang, Yu Ping
    Armstrong, Daniel Wayne
    Breitbach, Zachary S.
    Ryoo, Jae Jeong
    CHIRALITY, 2013, 25 (11) : 735 - 742
  • [10] Comprehensive strategy for chiral separations using sulfated cyclodextrins in capillary electrophoresis
    Evans, CE
    Stalcup, AM
    CHIRALITY, 2003, 15 (08) : 709 - 723
12345