Intimate details of the most poisonous poison

被引：115
|
作者：
Singh, BR [1 ]
机构：
[1] Univ Massachusetts, Dept Chem & Biochem, Dartmouth, MA 02747 USA
来源：
NATURE STRUCTURAL BIOLOGY | 2000年 / 7卷 / 08期
关键词：
D O I：
10.1038/77900
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Crystal structures of type B botulinum neurotoxin, determined under conditions relevant to the extracellular binding and intracellular substrate cleavage steps of its toxic action, reveal that minimal structural changes occur upon binding a ganglioside or after substrate cleavage. The unique structure of this toxin provides information for developing preventive measures against botulism.
引用
收藏
页码：617 / 619
页数：3
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