Larvicidal Activity of Cladonia substellata Extract and Usnic Acid against Aedes aegypti and Artemia salina

被引：0
|
作者：
Bomfim, Rangel R. [1 ]
Araujo, Adriano A. S. [1 ]
Cuadros-Orellana, Sara [2 ]
Melo, Marcelia G. D. [1 ]
Quintans-Junior, Lucindo J. [1 ]
Cavalcanti, Socrates C. H. [1 ]
机构：
[1] Univ Fed Sergipe, Dept Fisiol, Lab Ensaios Farmaceut & Toxicidade, Sao Cristovao, SE, Brazil
[2] ITP, Lab Engn Bioproc, Aracaju, SE, Brazil
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2009年 / 28卷 / 04期
关键词：
Aedes aegypti; Artemia salina; Cladonia substellata; Larvicidal activity; Usnic acid; IN-VITRO; LICHENS; METABOLITES; RATS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The chloroform extract of Cladonia substellata Vainio was assayed against larvae of Aedes aegypti, the mosquito vector of Dengue fever and Artemia salina. The extract was tested at concentrations ranging from I to 15 ppm in an aqueous medium for 24 h. LC50 and LC90 were evaluated. Since the chloroform extract proved to be lethal for third to fourth instar larvae, downstream processing was undertaken to purify the active agents in the extract. The major compound in the chloroform extract was purified by crystallization followed by column chromatography to yield yellow crystals. Furthermore, usnic acid (UA) was evaluated for its larvicidal potential. The major compound in the chloroform extract, UA, exhibited LC50 of 6.6 ppm (6.1 to 7.0 ppm). Therefore, UA is most likely the active principle in C. substellata. UA showed to be toxic to A. salina, a reference organism in assays to evaluate the potential toxicity hazard to invertebrates in ecosystems.
引用
收藏
页码：580 / 584
页数：5
相关论文
共 50 条
  • [1] LARVICIDAL ACTIVITY OF LICHEN SECONDARY METABOLITES ATRANORIN AND (-)-USNIC ACID AGAINST THE YELLOW FEVER MOSQUITO Aedes aegypti
    Koc, Samed
    Tufan-Cetin, Ozge
    Candan, Mehmet
    Turk, Aysen
    Cetin, Huseyin
    [J]. FRESENIUS ENVIRONMENTAL BULLETIN, 2021, 30 (11): : 11938 - 11941
  • [2] LARVICIDAL ACTIVITY OF GRANDISIN AGAINST AEDES AEGYPTI
    Cabral, Marise M. O.
    Alencar, Jeronimo A.
    Guimaraes, Anthony E.
    Kato, Massuo J.
    [J]. JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION, 2009, 25 (01) : 103 - 105
  • [3] In vitro antimicrobial activity of the organic extract of Cladonia substellata Vainio and usnic acid against Staphylococcus spp. obtained from cats and dogs
    Moura, Jusciene B.
    de Vargas, Agueda C.
    Gouveia, Gisele V.
    Gouveia, Joao J. de S.
    Ramos-Junior, Juracy C.
    Botton, Sonia de A.
    Pereira, Eugenia C.
    da Costa, Mateus M.
    [J]. PESQUISA VETERINARIA BRASILEIRA, 2017, 37 (04): : 368 - 378
  • [4] Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis
    Silva, C. R.
    Marinho, K. S. N.
    Silva, T. D. S.
    Ferreira, D. K. S.
    Aguiar, G. M.
    Martins, M. C. B.
    Santos, K. R. P.
    Aguiar Junior, F. C. A.
    Santos, N. P. S.
    Pereira, E. C.
    Silva, N. H.
    [J]. BIOMED RESEARCH INTERNATIONAL, 2017, 2017
  • [5] LARVICIDAL ACTIVITY OF TAGETES ERECTA AGAINST AEDES AEGYPTI
    Marques, Marcia M. M.
    Morais, Selene M.
    Vieira, Icaro G. P.
    Vieira, Mariano G. S.
    Silva, Ana Raquel A.
    De Almeida, Raimundo Rafael
    Guedes, Maria Izabel F.
    [J]. JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION, 2011, 27 (02) : 156 - 158
  • [6] Larvicidal activity of the crude methanolic extract from leaves of Clibadium surinamense against Aedes aegypti
    Soares da Cruz, Andrely de Jesus
    da Silva e Silva, Wanessa Rendeiro
    Cruz, Juliana dos Santos
    Sampaio-Junior, Francisco Dantas
    Barros Monteiro, Maria Vivina
    Hamoy, Moises
    Scofield, Alessandra
    Goes-Cavalcante, Gustavo
    [J]. CIENCIA RURAL, 2023, 53 (05):
  • [7] Machaerium acutifolium compounds with larvicidal activity against Aedes aegypti
    Melo, Sebastiao J.
    Sousa, Joao Paulo B.
    Sa, Maira G.
    Morais, Lais S.
    Magalhaes, Natalia M. G.
    Gouveia, Fernando N.
    Albernaz, Lorena C.
    Espindola, Laila S.
    [J]. PEST MANAGEMENT SCIENCE, 2021, 77 (03) : 1444 - 1451
  • [8] Larvicidal activity of Ramalina usnea lichen against Aedes aegypti
    Moreira, Antonio S. N.
    Fernandes, Roberta O. S.
    Lemos, Francisco J. A.
    Braz-Filho, Raimundo
    Vieira, Ivo J. C.
    [J]. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2016, 26 (04): : 530 - 532
  • [9] Larvicidal activity of Ramalina usnea lichen against Aedes aegypti
    Antônio S. N. Moreira
    Roberta O. S. Fernandes
    Francisco J. A. Lemos
    Raimundo Braz-Filho
    Ivo J. C. Vieirae
    [J]. Revista Brasileira de Farmacognosia, 2016, 26 : 530 - 532
  • [10] Larvicidal activity of Cybistax antisyphilitica against Aedes aegypti larvae
    Rodrigues, AMS
    de Paula, JE
    Roblot, F
    Fournet, A
    Espíndola, LS
    [J]. FITOTERAPIA, 2005, 76 (7-8) : 755 - 757
12345