The Regulation of IL-10 Expression

被引：144

作者：

Gabrysova, Leona ^{[1
]}

Howes, Ashleigh ^{[1
]}

Saraiva, Margarida ^{[3
,4
]}

O'Garra, Anne ^{[1
,2
]}

机构：

[1] Natl Inst Med Res, MRC, Div Immunoregulat, London NW7 1AA, England

[2] Imperial Coll Healthcare NHS Trust, St Marys Hosp, Dept Resp Med, London W2 1NY, England

[3] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal

[4] ICVS 3Bs PT Govt Associate Lab, P-4710057 Braga Guimaraes, Portugal

来源：

INTERLEUKIN-10 IN HEALTH AND DISEASE | 2014年 / 380卷

基金：

英国医学研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; MESSENGER-RNA STABILITY; TUMOR-NECROSIS-FACTOR; FACTOR C-MAF; ARYL-HYDROCARBON RECEPTOR; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTOR; GENE-EXPRESSION; CUTTING EDGE;

D O I：

10.1007/978-3-662-43492-5_8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding of how IL-10 expression is controlled is critical in the design of immune intervention strategies. IL-10 is produced by almost all cell types within the innate (including macrophages, monocytes, dendritic cells (DCs), mast cells, neutrophils, eosinophils and natural killer cells) and adaptive (including CD4(+) T cells, CD8(+) T cells and B cells) immune systems. The mechanisms of IL-10 regulation operate at several stages including chromatin remodelling at the Il10 locus, transcriptional regulation of Il10 expression and post-transcriptional regulation of Il10 mRNA. In addition, whereas some aspects of Il10 gene regulation are conserved between different immune cell types, several are cell type-or stimulus-specific. Here, we outline the complexity of IL-10 production by discussing what is known about its regulation in macrophages, monocytes, DCs and CD4(+) T helper cells.

引用

页码：157 / 190

页数：34

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