Molecular Aspects of Anti-Atherosclerotic Effects of Short Peptides

被引：6

作者：

Khavinson, V. Kh ^{[1
,2
]}

Lin'kova, N. S. ^{[1
]}

Evlashkina, E. V. ^{[1
]}

Durnova, A. O. ^{[3
]}

Kozlov, K. L. ^{[1
]}

Gutop, O. E. ^{[1
]}

机构：

[1] Russian Acad Sci, St Petersburg Inst Bioregulat & Gerontol, St Petersburg 196140, Russia

[2] Russian Acad Sci, IP Pavlov Inst Physiol, St Petersburg 196140, Russia

[3] Russian Acad Med Sci, DO Ott Res Inst Obstet & Gynecol, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 158卷 / 01期

关键词：

short peptides; vascular endothelium; aging; atherosclerosis; INFLAMMATION; CELLS;

D O I：

10.1007/s10517-014-2713-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied molecular mechanisms of the vasoprotective effects of tripeptide T-38 and dipeptide RR-1. Short peptides T-38 and the RR-1 activate the processes of cell renewal in organotypic and dissociated cultures of vascular cells during aging by increasing the expression of Ki-67 and reducing the synthesis of p53 protein. T-38 and RR-1 reduce the synthesis of E-selectin, adhesion molecule involved in the formation of atherosclerotic plaques.

引用

页码：159 / 163

页数：5

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