Antigen-specific B cells in kidney transplantation

被引：2
|
作者：
Saba, Johnny Bou [1 ]
Cherukuri, Aravind [1 ,2 ]
机构：
[1] Univ Pittsburgh, Thomas E Starzl Transplantat Inst, Dept Surg, Pittsburgh, PA USA
[2] Univ Pittsburgh, Dept Med, Renal & Electrolyte Div, Pittsburgh, PA USA
来源：
KIDNEY INTERNATIONAL | 2022年 / 102卷 / 02期
关键词：
REJECTION; MEMORY;
D O I：
10.1016/j.kint.2022.04.040
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue, Burton et al. describe a convincing method to identify and enumerate human leukocyte antigen-specific B cells and subsets using biotinylated human leukocyte antigen proteins. Importantly, they demonstrate that these antigen-specific B cells are found at a greater frequency in sensitized kidney transplant recipients when compared with healthy volunteers. Finally, using an indirect antigenspecific enzyme-linked immunosorbent spot assay, they uncover the complexity of B- and T-cell interactions and the influence of regulatory T cells on such interactions in vitro.
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页码：233 / 235
页数：3
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